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Ayahuasca does more than alter consciousness it quiets the brain’s default mode network or DMN a key hub for self reflection and mind wandering studies show this suppression is linked to ego dissolution relief from depression and transformative experiences (PubMed)
How Ayahuasca Impacts the DMN
In a 2015 fMRI study ayahuasca significantly reduced activity in the posterior cingulate cortex and medial prefrontal cortex two core DMN regions (PubMed)
Ego Dissolution and Depression Relief
When the DMN quiets its voice the narrative of the self weakens this leads to what users call ego dissolution a state where rigid self focused patterns loosen up this can break cycles of rumination common in depression (Verywell Mind)
Lasting Brain Network Changes
Follow up imaging shows 24 hours after ayahuasca there is continued reduction in DMN connectivity plus increased coupling between salience and DMN networks changes linked to altered emotion and self awareness (PubMed)
Therapeutic Insights
By temporarily disrupting the DMN ayahuasca may allow the brain to reset old thought patterns modern theories like REBUS describe this as relaxed beliefs under psychedelics a mechanism that may boost emotional flexibility and creativity (PMC)
Conclusion
Ayahuasca’s suppression of the default mode network offers a unique window into human consciousness and mental health the quieting of self reflection can dissolve entrenched negative thoughts and open the brain to new perspectives and healing
